Generative Bayesian modeling to nowcast the effective reproduction number from line list data with missing symptom onset dates

by Adrian Lison, Sam Abbott, Jana Huisman, Tanja Stadler The time-varying effective reproduction numberRt is a widely used indicator of transmission dynamics during infectious disease outbreaks. Timely estimates ofRt can be obtained from reported cases counted by their date of symptom onset, which is generally closer to the time of infection than the date of report. Case counts by date of symptom onset are typically obtained from line list data, however these data can have missing information and are subject to right truncation. Previous methods have addressed these problems independently by first imputing missing onset dates, then adjusting truncated case counts, and finally estimating the effective reproduction number. This stepwise approach makes it difficult to propagate uncertainty and can introduce subtle biases during real-time estimation due to the continued impact of assumptions made in previous steps. In this work, we integrate imputation, truncation adjustment, andRt estimation into a single generative Bayesian model, allowing direct joint inference of case counts andRt from line list data with missing symptom onset dates. We then use this framework to compare the performance of nowcasting approaches with different stepwise and generative components on synthetic line list data for multiple outbreak scenarios and across different epidemic phases. We find that under reporting delays realistic for hospitalization data (50% of reports delayed by more than a week), int...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research