Telmisartan-Induced Myotoxicity in Patients with Essential Hypertension

Turk Kardiyol Dern Ars. 2024 Apr;52(3):217-219. doi: 10.5543/tkda.2023.22893.ABSTRACTDrug-related muscular adverse effects are relatively common among certain groups of drugs, such as statins and steroids. However, these adverse effects are less well-known for angiotensin receptor blockers (ARBs). It is proposed that telmisartan and irbesartan may cause myotoxicity via increased Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma) activity. Herein, we present two hypertensive patients in whom telmisartan-induced myotoxicity was observed. Therefore, physicians should be aware that telmisartan, along with some other ARBs, can also cause myopathy. Possible drug-drug interactions should be considered in cases of concomitant prescription of these agents with other myopathic drugs.PMID:38573089 | DOI:10.5543/tkda.2023.22893
Source: Turk Kardiyoloji Dernegi arsivi - Category: Cardiology Authors: Source Type: research