Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

High expression of phosphatidylinositol 4-kinase III alpha (PI4KIII α) correlates with poor survival rates in patients with hepatocellular carcinoma (HCC). In addition, Hepatitis C virus (HCV) infections activate PI4KIIIα and contribute to HCC progression. We aimed at mechanistically understanding the impact of PI4KIIIα on the progression of liver cancer and the potential contribution of HCV in this process.

Source: Gastroenterology - April 16, 2024 Category: Gastroenterology Authors: Cong Si Tran, Julia Kersten, Jingyi Yan, Marco Breinig, Thorben Huth, Tanja Poth, Ombretta Colasanti, Tobias Riedl, Suzanne Faure-Dupuy, Stefan Diehl, Lieven Verhoye, Teng-Feng Li, Marit Lingemann, Philipp Schult, Gustaf Ahl én, Lars Frelin, Florian Küh Tags: Basic and Translational - Liver Source Type: research