Evaluating the docetaxel effect in an animal model of polyarthritis

ConclusionDTX reduces the progression and joint destruction in rats induced by Complete Freund ’s Adjuvant which may due to inhibition of PAD4, TNF-α, IL-1β, VEGF, and ACPA. Also, methotrexate exhibited anti PAD4 effect.
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research