5- < em > N < /em > -Carboxyimino-6-aminopyrimidine-2,4(3 < em > H < /em > )-dione, a novel indicator for hypochlorite formation

In this study, we found that 5-N-carboxyimino-6-N-chloroaminopyrimidine-2,4(3H)-dione rapidly reacted with thiol compounds such as cysteine and glutathione to yield 5-N-carboxyimino-6-aminopyrimidine-2,4(3H)-dione, which was stable in human plasma unlike 5-N-carboxyimino-6-N-chloroaminopyrimidine-2,4(3H)-dione. 5-N-carboxyimino-6-aminopyrimidine-2,4(3H)-dione was produced upon uric acid degradation during myeloperoxidase-induced uric acid oxidation and lipopolysaccharide-induced pseudo-inflammation in collected 2,4(3H)-dione has potential as a marker for hypochlorite production in vivo.PMID:38510685 | PMC:PMC10948346 | DOI:10.3164/jcbn.23-67
Source: Journal of Clinical Biochemistry and Nutrition - Category: Nutrition Authors: Source Type: research