Progressive reduction of nuclear receptor Nr4a1 mediates age-dependent cognitive decline

DISCUSSION: Our results elucidate the mechanism of Nr4a1-dependent TrkB regulation in cognition and synaptic function, indicating that Nr4a1 is a target for the treatment of cognitive decline.HIGHLIGHTS: Nr4a1 is reduced in PBMCs and CA1 PyrNs with aging. Nr4a1 ablation in CA1 PyrNs impaired cognition and excitatory synaptic function. Nr4a1 overexpression in CA1 PyrNs ameliorated cognitive impairment of aged mice. Nr4a1 bound to TrkB promoter to enhance transcription. Blocking TrkB function compromised Nr4a1-induced cognitive improvement.PMID:38605605 | DOI:10.1002/alz.13819

Source: The Journal of Alzheimers Association - April 12, 2024 Category: Psychiatry Authors: Jiang Chen Zhi Zhang Ying Liu Lili Huang Yi Liu Dan Yang Xinyu Bao Pinyi Liu Yuhan Ge Qingqing Li Xin Shu Lushan Xu Yun Stone Shi Xiaolei Zhu Yun Xu Source Type: research