Applying exercise capacity and physical activity as single vs. composite endpoints for trials of cardiac rehabilitation interventions: Rationale, use-case, and a blueprint method for sample size calculation

CONCLUSIONS: Trialists may consider the utility of the composite endpoint for future studies in exercise-based cardiac rehabilitation, which could reduce sample size requirements. However, perhaps surprisingly at first, the composite endpoint could also lead to an increased sample size needed, depending on the observed baseline proportions in the trial population and the aim of the intervention.PMID:38621456 | DOI:10.1016/j.apmr.2024.04.004

Source: Health Physics - April 15, 2024 Category: Physics Authors: Anna Eleonora Carrozzo Veronique Cornelissen Arne C Bathke Jomme Claes Josef Niebauer Georg Zimmermann Gunnar Treff Stefan Tino Kulnik Source Type: research