Role of HNF4 α-cMyc Interaction in CDE Diet–Induced Liver Injury and Regeneration

This study investigated the role of the HNF4α-cMyc interaction in regulating liver injury and regeneration using the choline-deficient and ethionine-supplemented (CDE) diet model. Wild-type (WT), hepatocyte-specific HNF4α-knockout (KO), cMyc-KO, and HNF4α-cMyc double KO (DKO) mice were fed a CDE diet for 1 week to induce subacute liver injury.

https://ajp.amjpathol.org/article/S0002-9440(24)00123-8/fulltext?rss=yes

Source: American Journal of Pathology - April 6, 2024 Category: Pathology Authors: Manasi Kotulkar, Julia Barbee, Diego Paine-Cabrera, Dakota Robarts, Maura O ’Neil, Udayan Apte Tags: Regular article Source Type: research