Dual time-point [18F]FDG PET imaging for quantification of metabolic uptake rate: Evaluation of a simple, clinically feasible method

Semi-quantitative analysis of positron emission tomography (PET) images is commonly performed by measuring the standardized uptake value (SUV) [1 –3]. However, several factors can affect quantification via a single static PET scan at a late time-point post-injection (p.i.) [4]. PET radiopharmaceutical distribution is a dynamic process, and a compartmental model can describe the underlying mechanisms and provide additional kinetic parameters related to the underlying pathology. While several studies have shown the significant potential of dynamic imaging [3–10], this approach has some limitations for routine clinical use.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research