Advanced Smart Biomaterials for Regenerative Medicine and Drug Delivery Based on Phosphoramidite Chemistry: From Oligonucleotides to Precision Polymers

Biomacromolecules. 2024 Apr 12. doi: 10.1021/acs.biomac.4c00259. Online ahead of print.ABSTRACTOver decades of development, while phosphoramidite chemistry has been known as the leading method in commercial synthesis of oligonucleotides, it has also revolutionized the fabrication of sequence-defined polymers (SDPs), offering novel functional materials in polymer science and clinical medicine. This review has introduced the evolution of phosphoramidite chemistry, emphasizing its development from the synthesis of oligonucleotides to the creation of universal SDPs, which have unlocked the potential for designing programmable smart biomaterials with applications in diverse areas including data storage, regenerative medicine and drug delivery. The key methodologies, functions, biomedical applications, and future challenges in SDPs, have also been summarized in this review, underscoring the significance of breakthroughs in precisely synthesized materials.PMID:38608139 | DOI:10.1021/acs.biomac.4c00259

Source: Biomacromolecules - April 12, 2024 Category: Biochemistry Authors: Bo Yang Ting Cui Liang Guo Lianqiang Dong Jun Wu Yongzheng Xing Yun Xu Jian Chen Yufei Wang Zhonghui Cui Yuanchen Dong Source Type: research