Mice harboring the T316N variant in the GABA < sub > A < /sub > R γ < sub > 2 < /sub > subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway

CONCLUSION: We generated a new SHE mouse model and provided in vivo evidence that rare variants of GABRG2 contribute to seizure attacks during sleep in SHE.PMID:38604438 | DOI:10.1016/j.expneurol.2024.114775

Source: Experimental Neurology - April 11, 2024 Category: Neurology Authors: Yong-Li Jiang Liang Xia Jing-Jing Zhao Hui-Min Zhou Dan Mi Xuan Wang Yuan-Yuan Wang Chang-Geng Song Wen Jiang Source Type: research