Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1 downregulation and Wnt5a/NF- κB activation

CONCLUSION: Our findings elucidate the role of miR-374a-5p upregulation in the pathogenesis of psoriasis through inhibition of WIF1 and activation of the Wnt5a/NF-κB pathway, providing new potential therapeutic targets for psoriasis.PMID:38604345 | DOI:10.1016/j.cellsig.2024.111171

Source: Cellular Signalling - April 11, 2024 Category: Cytology Authors: Jing Ma Lu Gan Hongying Chen Lihao Chen Yu Hu Chao Luan Kun Chen Jiaan Zhang Source Type: research