Time-Varying Clearance in Milrinone Pharmacokinetics from Premature Neonates to Adolescents

ConclusionMilrinone is predominately renally eliminated and so renal function is an important covariate describing variability in clearance. Increasing clearance over time likely reflects increasing cardiac output and renal perfusion due to milrinone and return to baseline following CPB.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research