Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association

CONCLUSION: This study unveils a U shaped association between serum α-klotho levels and both all-cause and cancer-related mortality among middle-aged and elderly individuals with frailty in the United States. The identified serum α-klotho thresholds, at 714.8 pg/ml for all-cause mortality and 750.6 pg/ml for cancer-related mortality, hold promise as potential targets for interventions aimed at mitigating the risks of premature death and cancer within this vulnerable population.PMID:38602574 | PMC:PMC11008069 | DOI:10.1007/s40520-024-02730-w
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Source Type: research