A mutation panel comprising BRAF < sup > V600E < /sup > , NRAS < sup > Q61R < /sup > , and NRAS < sup > Q61H < /sup > replicated retrospective histopathological examination findings in differentiating benign goitre from malignant papillary thyroid cancer in a cohort of Malaysian patients

In conclusion, mutation panel comprising BRAFV600E, NRASQ61R, and NRASQ61H did not discriminate the two PTC subtypes but replicated the retrospective HPE findings in differentiating BTG from PTC. The application of this mutation panel in pre-operative diagnosis of thyroid nodules requires further validation in a larger sample size, preferably incorporating fineneedle aspirate biopsies.PMID:38155379
Source: Malaysian Journal of Pathology - Category: Pathology Authors: Source Type: research