Keratinocyte Piezo1 Mediates Paclitaxel-Induced Mechanical Hypersensitivity

In this study, we used inhibitory optogenetic and chemogenetic techniques to determine if keratinocytes contribute to the mechanical hypersensitivity induced by treatment with the chemotherapeutic drug Paclitaxel. We found that keratinocyte inhibition largely alleviates paclitaxel-induced mechanical hypersensitivity in mice.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research