The Persistence Of Rodent Mechanical Hypersensitivity Following Chronic Constriction Injury From Chronic Early-Life Stress

Early-life environment is increasingly implicated as a risk factor for chronic pain. We evaluate whether early intervention of standard maternal nurturement could reverse chronic early-life stress (CES)-induced mechanical hypersensitivity. We used limited bedding to invoke CES in offspring of rats from postnatal day (PND)2-9. From PND10-weaning, litters were transferred to standard cages, and offspring from half the CES-litters were housed with dams subjected to only standard conditions (fostered).
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research