Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation

CONCLUSION: Depressive state aggravates epileptic seizures, increases microglia activation, and elevates inflammation levels. SSA treatment can alleviate acute epileptic seizures in mouse models of depression possibly by suppressing microglia activation-mediated inflammation.PMID:38597443 | DOI:10.12122/j.issn.1673-4254.2024.03.13

Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: Y Xiong X Liang X Liang W Li Y Qian W Xie Source Type: research