Absorption and pharmacokinetics of bupivacaine after bilateral topical administration in tonsillar fossae for posttonsillectomy pain relief

In conclusion, this study shows that applying 4 mL of bupivacaine 5 mg/mL by a swab in the tons illar fossae posttonsillectomy yields very low plasma concentrations, suggesting its safe application without any risk of systemic toxic effects.

Source: Pharmacology Research and Perspectives - April 10, 2024 Category: Drugs & Pharmacology Authors: Kristin Sandal Berg, Ellisiv Seines, Peter G ál, Lise Løberg‐Emanuelsen, Audun Stubhaug, Erik Waage Nielsen, Olav Spigset Tags: ORIGINAL ARTICLE Source Type: research