The ART(N) of Keratinocytes Leading Neurons into the Skin

Chronic itch is the most burdensome symptom among patients with atopic dermatitis (AD). Itch negatively affects sleep and QOL. Itch provokes the desire to scratch, leading to the vicious itch-scratch cycle that worsens epidermal barrier function and contributes to disease induction (St änderet al, 2024). Recent advances in immunology and neurobiology have led to the elucidation of neuro-immune mechanisms underpinning itch. The itch sensation requires the generation of action potentials initiated in sensory nerve fibers in the periphery.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Commentary Source Type: research