Epiberberine: a potential rumen microbial urease inhibitor to reduce ammonia release screened by targeting UreG

In conclusion, our study clearly indicates that epiberberine is a promising candidate as a safe and effective inhibitor of rumen microbial urease and provides an optimal strategy and suitable feed additive for regulating nitrogen excretion in ruminants in the future. KEY POINTS: • Epiberberine is the most effective inhibitor of rumen urease from Rhizoma Coptidis. • Urease accessory protein UreG is an effective target for design of urease inhibitor. • Epiberberine may be used as natural feed additive to reducing NH3 release in ruminants.PMID:38587649 | PMC:PMC11001712 | DOI:10.1007/s00253-024-13131-4
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Source Type: research