Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hA β-KI) mice
DISCUSSION: These findings highlight a sex-dependent variation in the microbiomes of hAβ-KI mice and underscore the importance of considering the microbiome when designing studies that use murine models for AD.HIGHLIGHTS: Microbial diversity and the abundance of several species differed in human amyloid beta knock-in (hAβ-KI) females but not males. Correlations to Alzheimer's disease (AD) genotype were stronger for the microbiome than the metabolome. Microbiomes from hAβ-KI mice were distinct from 3xTg-AD mice. Cage effects accounted for most of the variance in the microbiome and metabolome.PMID:38572865 | DOI:10.1002/alz.13794
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Sage J B Dunham Julio Avelar-Barragan Jason A Rothman Eric D Adams Gina Faraci Stefania Forner Shimako Kawauchi Andrea J Tenner Kim N Green Frank M LaFerla Grant R MacGregor Mark Mapstone Katrine L Whiteson Source Type: research