Sex-specific associations between AD genotype and the microbiome of human amyloid beta knock-in (hA β-KI) mice

DISCUSSION: These findings highlight a sex-dependent variation in the microbiomes of hAβ-KI mice and underscore the importance of considering the microbiome when designing studies that use murine models for AD.HIGHLIGHTS: Microbial diversity and the abundance of several species differed in human amyloid beta knock-in (hAβ-KI) females but not males. Correlations to Alzheimer's disease (AD) genotype were stronger for the microbiome than the metabolome. Microbiomes from hAβ-KI mice were distinct from 3xTg-AD mice. Cage effects accounted for most of the variance in the microbiome and metabolome.PMID:38572865 | DOI:10.1002/alz.13794
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research