Combination of pathological, biochemical and behavioral evaluations for peripheral neurotoxicity assessment in isoniazid-treated rats

In this study, since the measurement of serum neurofilament light chain could detect changes earlier than pathological examination, it could be useful as a biomarker for peripheral neurotoxicity. Moreover, examination of semi-thin specimens and choline acetyltransferase immunostaining were useful for characterizing morphological neurotoxicity, and image analysis of semi-thin specimens enabled us to objectively show the pathological features.PMID:38584972 | PMC:PMC10995436 | DOI:10.1293/tox.2023-0094

Source: Journal of Toxicologic Pathology - April 8, 2024 Category: Toxicology Authors: Akane Kashimura Satomi Nishikawa Yuhei Ozawa Yui Hibino Takashi Tateoka Mao Mizukawa Hironobu Nishina Tetsuya Sakairi Takanori Shiga Naoyuki Aihara Junichi Kamiie Source Type: research