Discovery and Characterization of Linear Motif Mediated Protein-Protein Complexes

Adv Exp Med Biol. 2024;3234:59-71. doi: 10.1007/978-3-031-52193-5_5.ABSTRACTThere are myriads of protein-protein complexes that form within the cell. In addition to classical binding events between globular domains, many protein-protein interactions involve short disordered protein regions. The latter contain so-called linear motifs binding specifically to ordered protein domain surfaces. Linear binding motifs are classified based on their consensus sequence, where only a few amino acids are conserved. In this chapter we will review experimental and in silico techniques that can be used for the discovery and characterization of linear motif mediated protein-protein complexes involved in cellular signaling, protein level and gene expression regulation.PMID:38507200 | DOI:10.1007/978-3-031-52193-5_5

Source: Advances in Experimental Medicine and Biology - March 20, 2024 Category: Research Authors: Andr ás Zeke Anita Alexa Attila Rem ényi Source Type: research