The frequencies distribution of CYP3A5 rs776746 and ABCB1 rs1045642 polymorphisms in the west Algerian population and relationships with pharmacogenetics

Conclusion: The difference in the allelic and genotypic distribution of these polymorphisms emphasize the need for dose adjustmentsin drugs metabolized by CYP3A5 and transported by ABCB1 to optimize treatments outcomes.Keywords: CYP3A5; ABCB1; genetic polymorphism; pharmacogenetics; West Algeria.

Source: African Health Sciences - April 8, 2024 Category: African Health Authors: Amina Ammour, Meriem Aberkane, Abdallah Boudjema, Wefa Boughrara, Sounnia Mediene Benchekor Source Type: research