Antifungal activity of extracts from < em > Justicia < /em > species against < em > Fusarium graminearum < /em >

Nat Prod Res. 2024 Apr 5:1-6. doi: 10.1080/14786419.2024.2334334. Online ahead of print.ABSTRACTFusarium graminearum causes destructive ear rot diseases in maize and wheat. New antifungals are essential to combat this pathogen, and aerial parts of Justicia species (Acanthaceae) are a potential source. We investigated the antifungal activity of extracts from stems and leaves of five Justicia species native to Northwest Argentina. The aerial parts were subjected to sequential extractions with dichloromethane, ethyl acetate, and methanol. The resulting extracts were tested by the disc diffusion method against F. graminearum strains. Only the leaf and stem extracts from J. xylosteoides displayed inhibitory effects, with the dichloromethane leaf extract as the most active. The compounds involved were identified as the lignans hinokinin, savinin, and isohibalactone. Both the dichloromethane extract and hinokinin synergised with tebuconazole, and inhibited deoxynivalenol biosynthesis. The identified compounds warrant further research as additives to azole fungicides for F. graminearum control.PMID:38579277 | DOI:10.1080/14786419.2024.2334334

Source: Natural Product Research - April 5, 2024 Category: Biochemistry Authors: Mariana Del H Sanchez Mat ías Anal ía de Los A Gómez Cristina M Jim énez Sarah Tanguy Guillo Mar ía Eugenia Del M Aristimuño Ficoseco C ésar A N Catalán Rapha ël Grougnet Marina Kritsanida Diego A Sampietro Source Type: research