A metabolic perspective to sleep genetics

Curr Opin Neurobiol. 2024 Apr 5;86:102874. doi: 10.1016/j.conb.2024.102874. Online ahead of print.ABSTRACTThe metabolic signals that regulate sleep and the metabolic functions that occur during sleep are active areas of research. Prior studies have focused on sugars and nucleotides but new genetic evidence suggests novel functions of lipid and amino acid metabolites in sleep. Additional genetic studies of energetic signaling pathways and the circadian clock transcription factor network have increased our understanding of how sleep responds to changes in the metabolic state. This review focuses on key recent insights from genetic experiments in humans and model organisms to improve our understanding of the interrelationship between metabolism and sleep.PMID:38582021 | DOI:10.1016/j.conb.2024.102874
Source: Current Opinion in Neurobiology - Category: Neurology Authors: Source Type: research