Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury

CONCLUSION: UGT1A1 is upregulated as a compensatory response during liver injury, and interference with this upregulation process may worsen liver injury. UGT1A1 reduces ER stress, oxidative stress, and lipid metabolism disorder, thereby mitigating hepatocyte apoptosis and necroptosis.PMID:38577195 | PMC:PMC10989491 | DOI:10.3748/wjg.v30.i9.1189

Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Jin-Lian Jiang Yi-Yang Zhou Wei-Wei Zhong Lin-Yan Luo Si-Ying Liu Xiao-Yu Xie Mao-Yuan Mu Zhi-Gang Jiang Yuan Xue Jian Zhang Yi-Huai He Source Type: research