Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

This study offers a network perspective on p53 stability regulation, potentially guiding strategies to reinforce wild-type p53 or target mutant p53 in cancer.PMID:38580884 | DOI:10.1038/s44320-024-00032-x

Source: Mol Biol Cell - April 5, 2024 Category: Molecular Biology Authors: YiQing L ü Tiffany Cho Saptaparna Mukherjee Carmen Florencia Suarez Nicolas S Gonzalez-Foutel Ahmad Malik Sebastien Martinez Dzana Dervovic Robin Hyunseo Oh Ellen Langille Khalid N Al-Zahrani Lisa Hoeg Zhen Yuan Lin Ricky Tsai Geraldine Mbamalu Varda Rot Source Type: research