Cancers, Vol. 16, Pages 1429: Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma & mdash;Insights from a Multicentre Retrospective Study

Cancers, Vol. 16, Pages 1429: Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma—Insights from a Multicentre Retrospective Study Cancers doi: 10.3390/cancers16071429 Authors: Giacomo Di Filippo Gian Luigi Canu Giovanni Lazzari Dorin Serbusca Eleonora Morelli Paolo Brazzarola Leonardo Rossi Benard Gjeloshi Mariangela Caradonna George Kotsovolis Ioannis Pliakos Efthymios Poulios Theodosios Papavramidis Federico Cappellacci Pier Francesco Nocini Pietro Giorgio Calò Gabriele Materazzi Fabio Medas Obesity’s role in thyroid cancer development is still debated, as well as its association with aggressive histopathological subtypes (AHSs). To clarify the link between Body Mass Index (BMI) and AHS of differentiated thyroid carcinoma (DTC), we evaluated patients who underwent thyroidectomy for DTC from 2020 to 2022 at four European referral centres for endocrine surgery. Based on BMI, patients were classified as normal-underweight, overweight, or obese. AHSs were defined according to 2022 WHO guidelines. Among 3868 patients included, 34.5% were overweight and 19.6% obese. Histological diagnoses were: 93.6% papillary (PTC), 4.8% follicular (FTC), and 1.6% Hürthle cell (HCC) thyroid carcinoma. Obese and overweight patients with PTC had a higher rate of AHSs (p = 0.03), bilateral, multifocal tumours (p = 0.014, 0.049), and larger nodal metastases (p = 0....
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research