Cancers, Vol. 16, Pages 1429: Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma & mdash;Insights from a Multicentre Retrospective Study
Cancers, Vol. 16, Pages 1429: Exploring the Link between BMI and Aggressive Histopathological Subtypes in Differentiated Thyroid Carcinoma—Insights from a Multicentre Retrospective Study
Cancers doi: 10.3390/cancers16071429
Authors:
Giacomo Di Filippo
Gian Luigi Canu
Giovanni Lazzari
Dorin Serbusca
Eleonora Morelli
Paolo Brazzarola
Leonardo Rossi
Benard Gjeloshi
Mariangela Caradonna
George Kotsovolis
Ioannis Pliakos
Efthymios Poulios
Theodosios Papavramidis
Federico Cappellacci
Pier Francesco Nocini
Pietro Giorgio Calò
Gabriele Materazzi
Fabio Medas
Obesity’s role in thyroid cancer development is still debated, as well as its association with aggressive histopathological subtypes (AHSs). To clarify the link between Body Mass Index (BMI) and AHS of differentiated thyroid carcinoma (DTC), we evaluated patients who underwent thyroidectomy for DTC from 2020 to 2022 at four European referral centres for endocrine surgery. Based on BMI, patients were classified as normal-underweight, overweight, or obese. AHSs were defined according to 2022 WHO guidelines. Among 3868 patients included, 34.5% were overweight and 19.6% obese. Histological diagnoses were: 93.6% papillary (PTC), 4.8% follicular (FTC), and 1.6% Hürthle cell (HCC) thyroid carcinoma. Obese and overweight patients with PTC had a higher rate of AHSs (p = 0.03), bilateral, multifocal tumours (p = 0.014, 0.049), and larger nodal metastases (p = 0....
Source: Cancers - Category: Cancer & Oncology Authors: Giacomo Di Filippo Gian Luigi Canu Giovanni Lazzari Dorin Serbusca Eleonora Morelli Paolo Brazzarola Leonardo Rossi Benard Gjeloshi Mariangela Caradonna George Kotsovolis Ioannis Pliakos Efthymios Poulios Theodosios Papavramidis Federico Cappellacci Pier Tags: Article Source Type: research
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