Role of HNF4alpha-cMyc Interaction in CDE-diet Induced Liver Injury and Regeneration

This study investigated the role of HNF4α-cMyc interaction in regulating liver injury and regeneration using the cho line-deficient and ethionine-supplemented (CDE) diet model. WT, hepatocyte-specific HNF4α-KO, cMyc-KO, and HNF4α-cMyc double knockout (DKO) mice were fed a CDE diet for one week to induce subacute liver injury.

https://ajp.amjpathol.org/article/S0002-9440(24)00123-8/fulltext?rss=yes

Source: American Journal of Pathology - April 6, 2024 Category: Pathology Authors: Manasi Kotulkar, Julia Barbee, Diego Paine-Cabrera, Dakota Robarts, Maura O ’Neil, Udayan Apte Tags: Regular Article Source Type: research