Reversible and monitorable nephrotoxicity in rats by the novel potent transcriptional enhanced associate domain (TEAD) inhibitor, K-975

In conclusion, this study revealed that in rats, oral K-975 treatment induced severe proteinuria by podocyte foot process effacement, which was reversible and monitorable by the urinary albumin index, suggesting important information for developing K-975 as an anticancer drug.PMID:38556354 | DOI:10.2131/jts.49.175

Source: Journal of Toxicological Sciences - March 31, 2024 Category: Toxicology Authors: Hironori Otsuki Takeshi Uemori Yohei Inai Yui Suzuki Tetsuro Araki Ken-Ichiro Nan-Ya Kouichi Yoshinari Source Type: research