Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system

In conclusion, our findings first provided new evidence for GA as an inducer of ferroptosis, and Nrf2-mediated GSH/Trx dual antioxidant system played an important role in GA-induced ferroptosis.PMID:38570172 | DOI:10.1016/j.freeradbiomed.2024.03.023

Source: Free Radical Biology and Medicine - April 3, 2024 Category: Biology Authors: Jinshuai Lan Li Liu Wenjun Zhao Zhe Li Ruifeng Zeng Shiyuan Fang Lixia Chen Yi Shen Hai Wei Tong Zhang Yue Ding Source Type: research