Systemic inflammation, the peripheral blood transcriptome and primary melanoma

Peripheral blood transcriptomes from 383 newly-diagnosed melanoma patients were subjected to differential gene expression analysis. The hypotheses were that impaired systemic immunity is associated with poorer prognosis (thicker tumors and fewer tumor infiltrating lymphocytes (TILs)) and evidence of systemic inflammation (high-sensitivity C-reactive protein (hsCRP) and fibrinogen levels). Higher fibrinogen levels were associated with thicker primaries. In single gene analysis hsCRP levels were significantly associated with higher blood CD274 expression, (coding for PD-L1), but each was independently prognostic, with hsCRP associated with increased mortality, and higher CD274 protective, independent of age.

Source: Journal of Investigative Dermatology - April 5, 2024 Category: Dermatology Authors: Juliette Randerson-Moor, John Davies, Mark Harland, J érémie Nsengimana, Theophile Bigirumurame, Christopher Walker, Jon Laye, Elizabeth S, Appleton, Graham Ball, Graham P. Cook, D Timothy Bishop, Robert J. Salmond, Julia Newton-Bishop Tags: Original Article Source Type: research