RNase H-dependent DNA thresholder modulated by cancer marker concentration

Chem Commun (Camb). 2024 Apr 2. doi: 10.1039/d4cc00495g. Online ahead of print.ABSTRACTThreshold antisense oligonucleotide constructs were designed to cleave mRNA within different biomarker concentrations. The mRNA cleavage is activated by 2.6, 7.5 or 39.5 nM of biomarker depending on the construct design. The constructs can be used to differentiate cancer from normal cells by the level of oncogene expression followed by silencing of a targeted gene.PMID:38563262 | DOI:10.1039/d4cc00495g

Source: Chemical Communications - April 2, 2024 Category: Chemistry Authors: Moustapha A Y Nour Valeriia S Drozd Evgenii A Lemeshko Lilia Tafran Adeliia A Salimova Alexandra V Kulikova Ahmed A Eldeeb Source Type: research