Molecular recognition and proteoglycan mimic arrangement: modulating cisplatin toxicity

Chem Commun (Camb). 2024 Apr 3. doi: 10.1039/d4cc00464g. Online ahead of print.ABSTRACTWe have demonstrated that cisplatin (CP), an anticancer drug, showed a preference for binding the sulfated-L-iduronic acid (S-L-IdoA) unit over the sulfated-D-glucuronic acid unit of heparan sulfate. The multivalency of S-L-IdoA, such as in the proteoglycan mimic, resulted in distinct modes of cell-surface engineering in normal and cancer cells, with these disparities having a significant impact on CP-mediated toxicity.PMID:38567462 | DOI:10.1039/d4cc00464g

Source: Chemical Communications - April 3, 2024 Category: Chemistry Authors: Saurabh Anand Sandhya Mardhekar Preeti Ravindra Bhoge Sandeep Kumar Mishra Raghavendra Kikkeri Source Type: research