New anti-inflammatory limonoids from the fruits of < em > Melia azedarach < /em >

Nat Prod Res. 2024 Apr 4:1-8. doi: 10.1080/14786419.2024.2335667. Online ahead of print.ABSTRACTThe phytochemical study of the fruits of Melia azedarach (Meliaceae) led to the isolation and characterisation of two novel natural limonoids1-deoxy- 3, 20-dicinnamoyl-11-methoxy-meliacarpinin (1) and 12β- O- methyl nimbolinin A (2), along with twelve known limonoids. Its structure was identified by 1D- and 2D-NMR, HR-ESI-MS and comparison with published data. The anti-inflammatory effect of the compounds was measured in vitro in RAW 264.7 cells by evaluating the production of NO stimulated by LPS. Compounds 1, 8 and 14 indicated significant anti-inflammatory effect with inhibition rate of 11.76, 8.45 and 6.59 μM, respectively. Limonoid 1 significantly inhibited the production of NO, TNF-α and IL-1β in RAW 264.7 cells. Therefore, limonoid derivative may be a promising source of bioactive metabolite for inflammatory diseases.PMID:38572741 | DOI:10.1080/14786419.2024.2335667

Source: Natural Product Research - April 4, 2024 Category: Biochemistry Authors: Fan Cao Jin-Huang Shen Zhi-Jun Li Wen-Lu Wang Zhen-Wei Chen Yong-Hong Zhang Xin-Hua Ma Source Type: research