Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy

In conclusion, we identified different metabolic pathways that underlie the diverse humoral responses triggered by COVID-19 mRNA vaccines during pregnancy. Our data hold significant implications for refining COVID-19 vaccination approaches in expectant mothers.Key messagesAnti-SARS-CoV-2 antibody titers decline as the number of days since COVID-19 vaccination increases.Anti-SARS-CoV-2 antibody titers are inversely associated with acetate, a microbial-derived metabolite, and urea.Amino acid metabolism is significantly associated with SARS-CoV-2 antibody titers.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research