Cancers, Vol. 16, Pages 1408: Colorectal Cancer Pulmonary Metastasectomy: When, Why and How

Cancers, Vol. 16, Pages 1408: Colorectal Cancer Pulmonary Metastasectomy: When, Why and How Cancers doi: 10.3390/cancers16071408 Authors: Francesco Petrella Federica Danuzzo Maria Chiara Sibilia Sara Vaquer Raffaella Longarini Alessandro Guidi Federico Raveglia Lidia Libretti Emanuele Pirondini Andrea Cara Enrico Mario Cassina Antonio Tuoro Diego Cortinovis Colorectal cancer is the third-most-diagnosed cancer in males and in females, representing 8% of estimated new cases, and the third cause of cancer-related death in both sexes, accounting for 9% of cancer deaths in men and 8% in women. About 20% of patients diagnosed with CRC present metastatic disease. Although lung metachronous or synchronous metastatic spread without other involved sites has been reported in only a small proportion of patients, considering that this tumor is frequently diagnosed, the clinical approach to CRC pulmonary metastases represents a major issue for thoracic surgeons and CRC oncologists. Among patients diagnosed with pulmonary metastases from CRC, about 9–12% are eligible for local treatments with radical intent, including surgical resection, SBRT (stereotactic body radiation therapy) and ablation therapy. Due to the lack of randomized controlled trials among different local strategies, there is no definitive evidence about the optimal approach, although surgical resection is considered the most effective therapeutic option in this clinical scenario....
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research