Effect of a single small volume fluid bolus with balanced or un-balanced fluids on chloride and acid-base status: a prospective randomized pilot study (the FLURES-trial)

CONCLUSION: Even a single, small bolus of saline, administered to critically ill patients, causes a significant increase in chloride concentration and a decrease in apparent strong ion difference and base excess, and an increase in the number of patients developing hyperchloremia. No difference in effect on urinary output, blood pressure or vasopressor need was observed between the two groups.EUDRACT NUMBER: 2014-001005-41; date of registration: 28/10/2014.LOCAL EC APPROVAL: EC project number 2014/038.PMID:38546940 | DOI:10.1007/s40620-024-01912-z
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Source Type: research