Colesevelam has no acute effect on postprandial GLP-1 levels but abolishes gallbladder refilling

CONCLUSION: Single-dose colesevelam had no effect on postprandial GLP-1 responses or glucose tolerance but disrupted postprandial gallbladder refilling by increasing CCK secretion and reducing circulating concentrations of FGF19 and bile acids. These findings leave the antidiabetic actions of colesevelam unresolved but provide mechanistic insights into its effect on gallbladder motility.PMID:38551029 | DOI:10.1093/ejendo/lvae033

Source: European Journal of Endocrinology - March 29, 2024 Category: Endocrinology Authors: Ida M Gether Emilie Bahne Henriette H Nerild Jens F Rehfeld Bolette Hartmann Jens J Holst Tina Vilsb øll David P Sonne Filip K Knop Source Type: research