Cancers, Vol. 16, Pages 1372: The Impact of Radiofrequency Ablation on Survival Outcomes and Stent Patency in Patients with Unresectable Cholangiocarcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Cancers, Vol. 16, Pages 1372: The Impact of Radiofrequency Ablation on Survival Outcomes and Stent Patency in Patients with Unresectable Cholangiocarcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Cancers doi: 10.3390/cancers16071372
Authors:
Daniele Balducci
Michele Montori
Francesco Martini
Marco Valvano
Federico De Blasio
Maria Eva Argenziano
Giuseppe Tarantino
Antonio Benedetti
Emanuele Bendia
Marco Marzioni
Luca Maroni
Endoluminal biliary radiofrequency ablation (RFA) has been proposed as a palliative treatment for patients with malignant biliary obstruction (MBO) in order to improve stent patency and survival. However, the existing data on patients with inoperable extrahepatic cholangiocarcinoma (eCCA) are conflicting. We performed a meta-analysis of randomized trials comparing RFA plus stenting versus stenting alone in patients with inoperable eCCA. We searched for trials published in the PubMed/MEDLINE, Scopus, and Cochrane databases up to November 2023. Data extraction was conducted from published studies, and a quality assessment was carried out in accordance with the guidelines recommended by the Cochrane Collaboration. Hazard ratios (HRs) with 95% CI were estimated from the trials. The primary endpoints of interest were overall survival and stent patency. Out of 275 results, 5 randomized trials and 370 patients were included. While overall survival was not different between the groups (HR 0.62; 95% CI 0.36&...
Source: Cancers - Category: Cancer & Oncology Authors: Daniele Balducci Michele Montori Francesco Martini Marco Valvano Federico De Blasio Maria Eva Argenziano Giuseppe Tarantino Antonio Benedetti Emanuele Bendia Marco Marzioni Luca Maroni Tags: Systematic Review Source Type: research
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