Revised HLA-DP TCE-Core Permissiveness Model Better Defines Relapse Risk and Survival Following Haploidentical Transplant

Haploidentical donor transplantation (HIDT) utilizing post-transplant cyclophosphamide (PTCy) is an increasing utilized donor source worldwide for patients lacking fully matched related or unrelated donors.1,2 As most patients have more than one available potential haploidentical donor options, selection criteria are needed to optimize HIDT outcomes. Younger donor age appears to be the most consistent predictive variable for transplant outcome after PTCy-based HIDT.3-6 More recently, there has been greater appreciation regarding the protective effects of increased class II HLA disparity at the HLA-DR and HLA-DP loci on transplant outcome.

Source: Biology of Blood and Marrow Transplantation - March 30, 2024 Category: Hematology Authors: Scott R Solomon, Michael T Aubrey, Lizamarie Bachier-Rodriguez, Melhem M Solh, Katelin C Jackson, Xu Zhang, Christina L Roark, H. Kent Holland, Lawrence E. Morris, Asad Bashey Source Type: research