Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration

This study sheds light on the regulatory function of FCGR2A in macrophage polarization, offering novel insights for IDD intervention strategies. KEY POINTS: This study unveils the role of FCGR2A in intervertebral disc (IVD) degeneration (IDD). FCGR2A knockdown mitigates IDD in cellular and animal models. Single-cell RNA-sequencing uncovers diverse macrophage subpopulations in degenerated IVDs. This study reveals the molecular mechanism of FCGR2A in regulating macrophage polarization. This study confirms the role of the NF-κB/STAT3 pathway in regulating macrophage polarization in IDD.PMID:38544414 | DOI:10.1113/JP285871

Source: The Journal of Physiology - March 28, 2024 Category: Physiology Authors: Jiaying Luo Guoxin Jin Shaoqian Cui Huan Wang Qi Liu Source Type: research