An Intra-Hospital Spread of Colistin-Resistant < em > K. pneumoniae < /em > Isolates-Epidemiological, Clinical, and Genetic Analysis

Conclusions: The study describes a within-hospital spread of two clones of COLr CR-Kp with a 60% mortality rate. Clone A isolates were coproducers of NDM-like and OXA-48-like enzymes and had mgrB-mediated colistin resistance. Clone B isolates had only OXA-48-like enzymes and intact mgrB genes. No plasmid-mediated resistance was found. The extremely high mortality rate and limited treatment options warrant strict measures to prevent outbreaks.PMID:38541237 | DOI:10.3390/medicina60030511

Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Georgi Popivanov Rumyana Markovska Ivanka Gergova Marina Konaktchieva Roberto Cirocchi Kirien Kjossev Ventsislav Mutafchiyski Source Type: research