Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology

Bronchial asthma (BA) is a common chronic disease affecting 300 million people globally,1 with up to 10% of patients presenting with severe BA. BA is a complex respiratory disease characterized by airway inflammation, bronchial hyperresponsiveness, and variable airflow limitation2 and is often complicated by rhinitis and chronic rhinosinusitis with nasal polyps (CRSwNP).3 BA is heterogenous, with variable phenotypes and endotypes, and therefore can be difficult to diagnose and treat.4 While the one-airway –one-disease hypothesis proposed that the upper and lower airways share a similar pathophysiology,5 the mechanisms underlying BA are diverse, with different and sometimes overlapping endotypes.

Source: Journal of Allergy and Clinical Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Hanako Yoshimura, Yoshito Takeda, Yuya Shirai, Makoto Yamamoto, Daisuke Nakatsubo, Saori Amiya, Takatoshi Enomoto, Reina Hara, Yuichi Adachi, Ryuya Edahiro, Moto Yaga, Kentaro Masuhiro, Taro Koba, Miho Itoh-Takahashi, Mana Nakayama, So Takata, Yuki Hosono Source Type: research