The Effect of Inhibition of Perisynaptic Astrocyte Glycogen Utilization on Depression-Like Behavior

CONCLUSION: The inhibition of glycogen use in the hippocampus by DAB did not affect anxiety-like and depression-like behaviors 3 and 5 days after injection in both female and male mice. The increase in the time spent in the open-field by male experimental group mice was associated not with anxiety, but with increase in the locomotor activity. The fact that no significant difference was observed in the light-dark box test, which is another test used to evaluate anxiety, supported this opinion. The increase seen in the sucrose preference test in female experimental group mice was not interpreted as an increase in hedonic behavior because prevention of glycogen breakdown in the hypothalamus might have homeostatically increased sugar-craving and therefore resulted in an increase in sucrose preference. Different set of tests better targeting the energy and glucose metabolism and applied at farther time points than surgery are recommended for future studies.PMID:38173328 | PMC:PMC10786353 | DOI:10.5080/u27208

Source: Turk Psikiyatri Dergisi - January 4, 2024 Category: Psychiatry Authors: Erknaz Ecehan Erk Buket Nebiye Demir H ülya Karataş Kurşun M üge Yemişçi Özkan Turgay Dalkara Emine Eren Ko çak Source Type: research