Targeted and shallow whole genome sequencing identifies therapeutic opportunities in p53abn endometrial cancers

CONCLUSIONS: sWGS and targeted sequencing identified therapeutic opportunities in 75% of p53abn EC patients. Further research is needed to determine the efficacy of treatments targeting these identified pathways within p53abn ECs.PMID:38536067 | DOI:10.1158/1078-0432.CCR-23-3689

Source: Clinical Cancer Research - March 27, 2024 Category: Cancer & Oncology Authors: Amy Jamieson Juliana Sobral de Barros Dawn R Cochrane J Maxwell Douglas Sameer Shankar Branden J Lynch Samuel Leung Spencer Martin Janine Senz Amy Lum Yvette Drew C Blake Gilks David G Huntsman Jessica N McAlpine Source Type: research