Native myocardial T1 mapping using inversion recovery T1-weighted turbo field echo sequence

This study proposes the use of the inversion recoveryT1-weighted turbo field echo (IR-T1TFE) sequence for myocardialT1 mapping and compares the results obtained with those of the modified Look-Locker inversion recovery (MOLLI) method for accuracy, precision, and reproducibility. A phantom containing seven vials with differentT1 values was imaged, thereby comparing theT1 measurements between the inversion recovery spin-echo (IR-SE) technique, MOLLI, and the IR-T1TFE. The accuracy, precision, and reproducibility of theT1-mapping sequences were analyzed in a phantom study. Fifteen healthy subjects were recruited for the in vivo comparison of native myocardialT1 mapping using MOLLI and IR-T1TFE sequences. After myocardium segmentation, theT1 value of the entire myocardium was calculated. In the phantom study, excellent accuracy was achieved using IR-T1TFE for allT1 ranges. MOLLI displayed lower accuracy than IR-T1TFE (p =0.016), substantially underestimatingT1 at largeT1 values (>  1000 ms). In the in vivo study, the first mean myocardialT1 values  ± SD using MOLLI and IR-T1TFE were 1306  ± 70 ms and 1484 ± 28 ms, respectively, and the second were 1297 ± 68 ms and 1474 ± 43 ms, respectively. The native myocardialT1 obtained with MOLLI was lower than that of IR-T1TFE (p <  0.001). The reproducibility of native myocardialT1 mapping within the same sequence was not statistically significant (p = 0.11). This study demonstrates the utili...

Source: Radiological Physics and Technology - March 26, 2024 Category: Physics Source Type: research