Chromosome 12p13 variants contribute to large artery atherosclerotic stroke risk in a Chinese population

Recently, genome-wide association study (GWAS) identified two common variants (rs12425791 and rs11833579) on Chromosome 12p13 that confer risk for stroke. The aim of this study was to evaluate whether these two variants are associated with risk of large artery atherosclerotic (LAA) stroke in a Chinese population. Rs12425791 and rs11833579 were genotyped using the improved multiple ligase detection reaction in 423 patients with LAA stroke and 423 healthy controls. We found a statistically significantly increased risk of LAA stroke associated with the rs12425791AA genotype (OR=2.28, 95% CI=1.15-4.51) and rs11833579 AA genotype (OR=1.92, 95% CI=1.16-3.15) compared with their GG genotype.

Source: Journal of the Neurological Sciences - June 30, 2015 Category: Neurology Authors: Zhizhong Zhang, Gelin Xu, Wusheng Zhu, Wen Bai, Liping Cao, Yunyun Xiong, Min Li, Xiaobing Fan, Hua Li, Minmin Ma, Wenhua Liu, Renliang Zhang, George Liu, Xinfeng Liu Source Type: research